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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T80056 | Glutathione Peroxidase | GSH-Px,EC 1.11.1.9 | Glutathione Peroxidase |
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (GSSG) by forming a disulfide bridge, concurrently reducing hy... | |||
T37314 | JKE-1674 | GPX | |
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. | |||
T5340 | MPO-IN-28 | Glutathione Peroxidase | |
MPO-IN-28 is a novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM. | |||
T8375 | ML-210 | CID 49766530 | Ferroptosis , GPX , Glutathione Peroxidase , Ras |
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity | |||
T4090 | PF-06282999 | Glutathione Peroxidase | |
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases. | |||
T14379 | AZD5904 | Glutathione Peroxidase | |
AZD5904 is a potent and irreversible human Myeloperoxidase (MPO) inhibitor(IC50 of 140 nM and has similar potency in mouse and rat). | |||
T12189 | NBDHEX | Apoptosis , Glutathione Peroxidase , Autophagy | |
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) . | |||
T8970 | ML162 | Ferroptosis , GPX , Glutathione Peroxidase | |
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively) | |||
T5463 | Verdiperstat | AZD3241,AZD 3241 | Glutathione Peroxidase |
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders. | |||
T5372 | L-SelenoMethionine | L-(+)-Selenomethionine | Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite |
L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase. | |||
T83780 | GPX4 24 | Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24 | |
GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e... | |||
T3646 | RSL3 | RSL3 1S,1S,3R-RSL3 | Ferroptosis , GPX , Glutathione Peroxidase |
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS. | |||
T4313 | Tinoridine hydrochloride | Nonflamin,Y-3642 hydrochloride | COX , Glutathione Peroxidase |
Tinoridine hydrochloride (Y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. Tinoridine hydrochloride (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxid... | |||
TJS0338 | 4-Methylesculetin | 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin | Antioxidant , Glutathione Peroxidase |
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. | |||
T26389 | 4-POBN | NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH | Glutathione Peroxidase |
4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke. | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T19117 | 3-Deoxyglucosone | 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose | GPX , Glucagon Receptor |
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGE... | |||
T36935 | PKUMDL-LC-101-D04 | GPX4-Activator-1d4,PKUMDL-LC-101-D04 | GPX |
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free... | |||
T67498 | 3-Amino-1,2,4-triazole | Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B | Reactive Oxygen Species |
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathi... | |||
T11357 | Gamma-glutamylcysteine TFA | γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA) | IL Receptor |
Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), a crucial dipeptide in glutathione (GSH) synthesis and a vital cofactor for the enzyme glutathione peroxidase (GPx), significantly modulates inflammatory response... |